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Coulometric titrations are a form of titrimetric analysis where the reagent is generated electrically, and its amount is evaluated based on current and generating time. The electron serves as the standard reagent. The procedure is similar to conventional titrations, such as endpoint detection.
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Acid-base titration using a microfluidic thread-based analytical device (μTAD).

Purim Jarujamrus1, Akarapong Prakobkij, Sodsai Puchum

  • 1Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand. purim.j@ubu.ac.th.

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A new microfluidic thread-based analytical device (μTAD) offers a simple, cost-effective method for precise acid-base quantification. This innovative titration technique provides accurate results quickly for various real-world samples.

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Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Traditional titration methods can be time-consuming and require specialized equipment.
  • There is a need for simple, cost-effective analytical tools for acid-base quantification.

Purpose of the Study:

  • To develop and validate a novel microfluidic thread-based analytical device (μTAD) for acid-base titration.
  • To assess the accuracy, precision, and stability of the μTAD for real-world sample analysis.

Main Methods:

  • Fabrication of μTAD by immobilizing cotton threads and pre-coating with indicator and standard solution.
  • Application of μTAD for acid-base quantification by observing color change distance on the thread.
  • Validation of μTAD results against conventional titration methods.

Main Results:

  • The μTAD demonstrated a simple, cost-efficient, and high-precision method for acid-base quantification.
  • Analysis completed within 2 minutes with high accuracy and precision (RSD < 12.9%).
  • The μTAD showed good linearity, low limit of quantification, and stability for over 2 weeks.

Conclusions:

  • The developed μTAD is a viable and practical tool for rapid acid-base determination.
  • This approach offers a user-friendly and cost-effective alternative for chemical analysis in various sample types.
  • The μTAD's stability and ease of use make it suitable for diverse applications.