Association Between High-Sensitivity C-Reactive Protein and Idiopathic Adhesive Capsulitis

Area of Science:

• Orthopedics
• Rheumatology
• Clinical Chemistry

Background:

• Chronic inflammation is linked to idiopathic adhesive capsulitis (IAC).
• The association between high-sensitivity C-reactive protein (CRP) and IAC is not well-established.
• This study investigates the relationship between CRP levels and IAC, and associated metabolic factors.

Purpose of the Study:

• To determine if high-sensitivity CRP levels are associated with IAC.
• To identify metabolic factors linked to high-sensitivity CRP in patients with IAC.

Main Methods:

• A case-control study involving 202 IAC patients and 606 controls.
• Analysis of variables including BMI, diabetes, dyslipidemia, and serum levels of glucose, HbA1c, and CRP.
• Multivariable conditional logistic regression was used to evaluate associations.

Main Results:

• High-sensitivity CRP >1.0 mg/L was significantly associated with IAC (OR, 2.47).
• Diabetes, elevated fasting glucose, HbA1c, hypertriglyceridemia, hypo-high-density lipoproteinemia, and a high TG/HDL ratio were significantly associated with high-sensitivity CRP in IAC patients.

Conclusions:

• High-sensitivity CRP >1.0 mg/L is an independent marker associated with IAC.
• Dyslipidemia, insulin resistance, and hyperglycemia are linked to both high-sensitivity CRP and IAC.
• These findings support the role of chronic systemic inflammation in the development of IAC.