Related Experiment Video
Updated: Dec 22, 2025
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
5.8K
Outcomes for high-risk hepatoblastoma in a resource-challenged setting
A Rammohan1, M Rela2, G V Kumar1
1Institute of Liver Disease and Transplantation, Sree Balaji Medical College Hospital, Bharat Institute of Higher Education and Research, Chennai, India.
BJS Open
|May 8, 2020
Summary
High-risk hepatoblastoma treatment outcomes are improving, even in resource-limited settings. Surgical resection and liver transplantation offer comparable survival rates for pediatric liver cancer patients.
Area of Science:
- Pediatric Oncology
- Surgical Gastroenterology
- Hepatobiliary Surgery
Background:
- High-risk hepatoblastoma historically has poor outcomes, particularly in resource-limited regions.
- Limited access to chemotherapy and pediatric liver transplantation exacerbates challenges.
Purpose of the Study:
- To evaluate treatment outcomes for high-risk hepatoblastoma in a tertiary care setting.
- To assess the efficacy of non-transplant surgical procedures, including extended resection.
Main Methods:
- Retrospective review of high-risk hepatoblastoma patients treated from January 2012 to May 2018.
- Analysis of perioperative data and long-term survival outcomes.
- Comparison between surgical resection and liver transplantation groups.
Main Results:
- Of 22 high-risk hepatoblastoma cases, 17 underwent surgery (6 resection, 11 transplantation).
- Overall 1-, 3-, and 5-year survival rates were 77%, 64%, and 62% respectively.
- Survival rates for resection (100%, 83%, 83%) and transplantation (91%, 82%, 73%) were comparable.
Conclusions:
- Excellent outcomes for high-risk hepatoblastoma are achievable, even in resource-challenged environments.
- Surgical resection is a viable alternative to liver transplantation with similar survival benefits.
