Related Experiment Video
Updated: Dec 22, 2025
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Evolution of Systemic Therapy for Hepatocellular Carcinoma
Richard S Finn1, Andrew X Zhu2,3
1Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Abstract:
Despite being one of the leading causes of cancer death globally, hepatocellular carcinoma (HCC) has historically not been the focus of novel drug development. That has changed in the past several years, with the results from a number of hallmark phase 3 studies in advanced HCC. In HCC, immune-oncology approaches have garnered much attention; there is still a need to better understand criteria for patient selection and to optimize combination strategies to maximize the potential of these approaches. The next generation of studies will aim at translating our increased understanding of tumor biology into clinical trial design.
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