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Challenges in Matrix Metalloproteinases Inhibition
Helena Laronha1,2, Inês Carpinteiro1, Jaime Portugal3
1Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, 2829-511 Caparica, Portugal.
Biomolecules
|May 9, 2020
Summary
Matrix metalloproteinases (MMPs) degrade extracellular matrix. Developing synthetic MMP inhibitors is challenging due to issues like low selectivity and instability, necessitating further research into their properties.
Area of Science:
- Biochemistry
- Enzymology
- Molecular Biology
Background:
- Matrix metalloproteinases (MMPs) are crucial enzymes responsible for extracellular matrix (ECM) degradation.
- These enzymes play significant roles in various physiological and pathological processes.
- Modulating ECM degradation via MMP inhibition is a therapeutic target.
Purpose of the Study:
- To review and describe currently reported synthetic inhibitors of matrix metalloproteinases.
- To highlight the challenges associated with developing selective and stable synthetic MMP inhibitors.
Main Methods:
- Extensive literature review of synthetic matrix metalloproteinase inhibitors.
- Analysis and description of the properties of reported inhibitors.
Main Results:
- Synthetic inhibitor development faces challenges including low selectivity, specificity, clinical side effects, and instability.
- A comprehensive overview of existing synthetic MMP inhibitors and their characteristics is provided.
Conclusions:
- Despite challenges, synthetic MMP inhibitors offer potential for therapeutic applications.
- Further research is needed to overcome current limitations in synthetic MMP inhibitor design and development.
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