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Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples
Published on: June 30, 2023
A child with household transmitted COVID-19
Li-Juan Mao1, Jian Xu2, Zhi-Hao Xu3
1Department of Pediatrics, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, N1 Shangcheng Avenue, Yiwu, 322000, Zhejiang Province, China.
Insights
This study reports a mild pediatric case of Coronavirus Disease 2019 (COVID-19) acquired through household transmission. The child remained infectious for SARS-CoV-2 via stool and swabs for over two weeks post-recovery.
Area of Science:
- Pediatrics
- Infectious Diseases
- Virology
Background:
- Coronavirus Disease 2019 (COVID-19) affects all ages, but pediatric cases are less common.
- Understanding clinical differences in pediatric COVID-19 is crucial.
Observation:
- A 14-month-old boy presented with fever and mild COVID-19.
- The child contracted COVID-19 from household contacts (mother and grandmother).
- Chest CT showed ground glass opacities, resolving after treatment.
Findings:
- The pediatric patient exhibited normal lymphocyte counts.
- SARS-CoV-2 RNA remained detectable in nasopharyngeal swabs and stool 17 days after symptom resolution.
- Mild symptoms and household transmission were noted.
Implications:
- Pediatric COVID-19 cases may be contagious for extended periods post-recovery.
- Further research is needed on the prolonged shedding of SARS-CoV-2 in children.
- Clinical management of pediatric COVID-19 should consider potential post-recovery contagiousness.
Background:
Although people of all ages are susceptible to the novel coronavirus infection, which is presently named "Coronavirus Disease 2019" (COVID-19), there has been relatively few cases reported among children. Therefore, it is necessary to understand the clinical characteristics of COVID-19 in children and the differences from adults.
Case Presentation:
We report one pediatric case of COVID-19. A 14-month-old boy was admitted to the hospital with a symptom of fever, and was diagnosed with a mild form of COVID-19. The child's mother and grandmother also tested positive for SARS-CoV-2 RNA. However, the lymphocyte counts were normal. The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. The patient continued to test positive for SARS-CoV-2 RNA in the nasopharyngeal swabs and stool at 17 days after the disappearance of symptoms.
Conclusion:
The present pediatric case of COVID-19 was acquired through household transmission, and the symptoms were mild. Lymphocyte counts did not significantly decrease. The RNA of SARS-CoV-2 in stool and nasopharyngeal swabs remained positive for an extended period of time after the disappearance of symptoms. This suggests that attention should be given to the potential contagiousness of pediatric COVID-19 cases after clinical recovery.
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