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Updated: Dec 22, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

11.2K

Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases

Pedro A Dionísio1, Joana D Amaral1, Cecília M P Rodrigues1

  • 1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.

International Review of Cell and Molecular Biology
|May 9, 2020
PubMed

Insights

Necroptosis, a regulated cell death pathway involving RIP3 and MLKL, is implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. Targeting necroptosis offers potential therapeutic strategies for these conditions.

Area of Science:

  • Cell Biology
  • Neuroscience
  • Immunology

Background:

  • Necroptosis is a regulated form of necrosis dependent on RIP3 and MLKL.
  • This cell death pathway is activated by death receptors under specific pathological conditions.
  • Necroptosis is increasingly recognized for its role in neurodegenerative diseases.

Purpose of the Study:

  • To summarize the molecular mechanisms of necroptosis induction and its effectors.
  • To explore non-necroptotic functions of related proteins in cell death and inflammation.
  • To review the involvement of necroptosis in neurodegeneration and potential therapeutic targets.

Main Methods:

  • Literature review and synthesis of existing research on necroptosis.
  • Analysis of molecular pathways regulating necroptosis.
  • Examination of evidence linking necroptosis to neurodegenerative diseases.

Main Results:

  • Detailed description of the RIP1-RIP3-MLKL signaling axis in necroptosis.
  • Identification of necroptosis's role in the pathogenesis of Alzheimer's, Parkinson's, and multiple sclerosis.
  • Exploration of alternative functions of necroptosis-related proteins in cellular processes.

Conclusions:

  • Necroptosis is a key pathway in neuroinflammation and neurodegeneration.
  • Targeting necroptosis presents promising therapeutic avenues for neurological disorders.
  • Further research into necroptosis mechanisms and non-canonical roles is warranted.
Keywords:
MLKLMitochondriaNecroptosisNeurodegenerative diseasesRIP1/RIPK1RIP3/RIPK3ROSTNF-α

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