Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Caspases

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

Overview of Cell Death

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...

Export of Misfolded Proteins out of the ER

Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Cell‑autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53‑driven senescence and confers an immune‑active tumor microenvironment.

Molecular cancer·2026

Same author

The role of interleukin-6 in diabetic retinal disease: pathophysiology and therapeutic targeting.

Frontiers in immunology·2026

Same author

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis.

British journal of pharmacology·2026

Same author

[Why C-reactive protein is (usually) not high in SLE].

Zeitschrift fur Rheumatologie·2026

Same author

Insights from Interleukin-6 trans-signaling and implications for the control of cytokine activity.

Biochimica et biophysica acta. Molecular cell research·2026

Same author

Blockade of Interleukin-6 Trans-signaling in the Presence of Certain Gut Microbiota Induces Mature-onset Obesity in Mice.

Gastro hep advances·2025

Search research articles

Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

Necroptosis, ADAM proteases and intestinal (dys)function.

Michelle Heib¹, Stefan Rose-John², Dieter Adam¹

¹Institut für Immunologie, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.

International Review of Cell and Molecular Biology

|May 9, 2020

Summary

Necroptosis, a cell death pathway, and a disintegrin and metalloproteinase (ADAM) proteases are linked, impacting intestinal inflammation and homeostasis. This review explores their roles in health and disease.

Keywords:

ADAM proteases Apoptosis Cell death Colorectal cancer Inflammatory bowel disease Intestinal dysfunction MLKL Necroptosis RIPK3 TNF

More Related Videos

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

Related Experiment Videos

Last Updated: Dec 22, 2025

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

Area of Science:

Cell Biology
Immunology
Gastroenterology

Background:

Necroptosis is a regulated cell death pathway crucial for immunity and homeostasis.
A disintegrin and metalloproteinase (ADAM) proteases are key regulators of cellular processes.
Both pathways are implicated in intestinal inflammatory responses.

Purpose of the Study:

To review the physiology and pathophysiology of necroptosis and ADAM proteases.
To discuss their roles in intestinal function and dysfunction.
To explore the involvement of ADAMs in necroptotic signaling.

Main Methods:

Literature review of necroptosis and ADAM proteases.
Analysis of their roles in intestinal physiology and pathophysiology.
Synthesis of current knowledge on their interactions.

Main Results:

Necroptosis and ADAMs are critical for organismal homeostasis and immune defense.
Dysregulation of these pathways contributes to intestinal dysfunction.
ADAM proteases play a role in modulating necroptotic signaling.

Conclusions:

Understanding the interplay between necroptosis and ADAMs is vital for intestinal health.
Targeting these pathways may offer therapeutic strategies for inflammatory bowel diseases.
Further research is needed to elucidate the precise mechanisms of ADAMs in necroptosis.