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MSX1 is differentially expressed in the deepest impacted maxillary third molars
B Olsson1, R D Calixto1, N C da Silva Machado1
1Department of Stomatology, Department of Oral and Maxillofacial Surgery, Federal University of Paraná, Av. Prefeito Lothário Meissner, 632, Jardim Botânico, Curitiba, PR, 80210-170, Brazil.
Summary
The expression of msh homeobox 1 (MSX1) differs based on the impaction depth of maxillary third molars. RUNX2 and BMP2 gene expression showed no significant differences related to impaction classifications.
Area of Science:
- Oral and Maxillofacial Surgery
- Molecular Biology
- Dental Genetics
Background:
- Impacted third molars are common dental anomalies, influenced by factors like space, eruption timing, tooth bud position, and genetics.
- Understanding the molecular mechanisms behind impaction is crucial for predicting and managing these conditions.
Purpose of the Study:
- To investigate differential gene expression of RUNX2, BMP2, and MSX1 in impacted third molars.
- To correlate gene expression with impaction classifications (Winter's, Pell & Gregory) and tooth position.
Main Methods:
- Gene expression analysis of RUNX2, BMP2, and MSX1 in bone samples from 32 patients undergoing surgical removal of impacted third molars.
- Classification of impaction using orthopantomograms based on Winter's and Pell & Gregory's systems.
- Statistical analysis including Kruskal-Wallis, Dunn's post hoc, and Spearman's correlation tests.
Main Results:
- No significant correlations were found between the expression of RUNX2, BMP2, and MSX1.
- No differences in gene expression were observed between maxillary and mandibular molars or according to Winter's or Pell & Gregory's classifications.
- MSX1 gene expression was significantly different based on the depth of impaction in maxillary third molars (p=0.029).
Conclusions:
- MSX1 gene expression is associated with the depth of impaction specifically in maxillary third molars.
- RUNX2 and BMP2 gene expression do not appear to be significantly influenced by the impaction classifications studied.
