Related Experiment Video
Updated: Dec 22, 2025

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
[Immune Checkpoint Inhibitor Related Enterocolitis]
1Division of Gastroenterology and Hepatology, Dept. of Internal Medicine, Keio University School of Medicine.
Abstract:
Immune checkpoint inhibitors(ICI)have been rapidly extended their indication in various cancer types. On the other hand, immune-related adverse event(irAE)is observed in some cases and sometime causes fatal outcome. Enterocolitis is one of the major irAE, especially in the case treated with anti-CTLA-4 antibody. Although the combination therapy ofanti -CTLA-4 antibody and anti-PD-1 antibody has shown clinical benefit in some cancer types, a risk of enterocolitis is higher than monotherapy. Accumulated evidence has revealed the clinical features of enterocolitis caused by anti-CTLA-4 antibody and anti- PD-1/PD-L1 antibody. We summarize recent knowledge and discuss future perspectives.
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