Related Experiment Video
Updated: Dec 22, 2025

06:10
Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
Published on: May 9, 2025
794
Author Correction: Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell
Mohit Sachdeva1, Brian W Busser1, Sonal Temburni1
1Cellectis, Inc., 430 East 29th Street, New York, NY, 10016, USA.
Nature Communications
|May 9, 2020
Abstract:
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Related Concept Videos
Cell-mediated Immune Responses
83.0K
Overview
83.0K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Diversity of Antigen Receptors
1.3K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.3K

