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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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Related Experiment Video

Updated: Dec 22, 2025

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Plant Extracts for Sleep Disturbances: A Systematic Review.

S Guadagna1, D F Barattini1, S Rosu2

  • 1Opera Contract Research Organization Srl, A TIGERMED Company, Timisoara, Romania.

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|May 9, 2020
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Summary
This summary is machine-generated.

Oral plant extracts are generally safe sleep aids, but more research is needed to confirm their effectiveness for various sleep complaints. Valerian and lavender show potential but have conflicting results.

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Area of Science:

  • Pharmacology
  • Herbal Medicine
  • Sleep Science

Background:

  • Sleep complaints are prevalent, impacting physical, psychological, and socioeconomic well-being.
  • Numerous oral plant-based food supplements are marketed for sleep improvement.
  • Existing treatments for sleep disorders have limitations, driving interest in natural alternatives.

Purpose of the Study:

  • To systematically review recent literature on oral plant extracts for sleep disorders.
  • To differentiate the effects of plant extracts on specific sleep symptoms: sleep initiation/maintenance, early waking, and sleep quality.

Main Methods:

  • Searched PubMed for randomized, double-blind, placebo-controlled trials, noncontrolled trials, and cohort studies up to March 5, 2020.
  • Used search terms including "oral food supplement," "sleep disorders," and specific compound names.
  • Selected 7 compounds and 38 relevant reports for analysis.

Main Results:

  • Evidence for the clinical efficacy of many nutraceuticals for sleep is limited.
  • Valerian and lavender are the most studied plant extracts for sleep.
  • These extracts show potential anxiolytic effects and improvements in sleep quality/duration, though results are conflicting.

Conclusions:

  • Oral plant-based sleep aids are generally safe and well-tolerated.
  • High-quality research is required to validate the effectiveness of these supplements for specific sleep complaints.
  • Future research should explore combining plant extracts with sleep hygiene and identifying optimal products for targeted symptom relief.