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Ultrasonic Characteristics of Cardiovascular Changes in Children with Hutchinson-Gilford Progeria Syndrome: A

Xiao-Ni Zhao1, Hong-Ping Song1, Fan Yang1

  • 1Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032 Shaanxi Province, China.

Biomed Research International
|May 9, 2020
PubMed

Insights

Children with Hutchinson-Gilford progeria syndrome (HGPS) show impaired heart function and carotid artery changes similar to older adults, but distinct from natural aging. Cardiovascular assessment in HGPS reveals unique patterns.

Area of Science:

  • Cardiology
  • Pediatrics
  • Genetics

Background:

  • Cardiovascular characteristics in Hutchinson-Gilford progeria syndrome (HGPS) are not well understood.
  • HGPS is a rare genetic disorder characterized by premature aging.

Purpose of the Study:

  • To evaluate cardiovascular changes in children with HGPS using ultrasound.
  • To compare cardiovascular parameters in HGPS children with healthy children and older adults.

Main Methods:

  • Three-dimensional echocardiography with strain analysis and carotid elasticity examination using echo-tracking were performed.
  • Evaluated groups included seven HGPS children, 21 age-matched healthy children, and 14 older healthy volunteers.

Main Results:

  • HGPS children exhibited impaired left ventricular (LV) synchrony compared to healthy children.
  • Carotid artery structural abnormalities in HGPS children were similar to older adults.
  • While LV ejection fraction (LVEF) was not significantly different, HGPS children had lower average peak LV times.

Conclusions:

  • HGPS children demonstrate distinct cardiovascular changes compared to natural aging.
  • LV synchrony is impaired in HGPS children.
  • Carotid artery structure in HGPS resembles that of older individuals, suggesting accelerated vascular aging.
Abstract

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