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The effects of growth hormone on therapy resistance in cancer

Reetobrata Basu1,2, John J Kopchick1,2

  • 1Ohio University Heritage College of Osteopathic Medicine (OU-HCOM), Ohio University, Athens, OH 45701, USA.

Cancer Drug Resistance (Alhambra, Calif.)
|May 9, 2020
PubMed

Insights

Growth hormone (GH) and its receptor (GHR) play roles in cancer, impacting therapy resistance. Understanding these mechanisms is key for developing new cancer treatments.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Growth hormone (GH) regulates growth and metabolism.
  • GH and its receptor (GHR) are implicated in various cancers.
  • Mechanisms of GH/GHR in cancer prognosis and treatment are not fully understood.

Purpose of the Study:

  • To review the molecular mechanisms of GH-GHR signaling in cancer therapy resistance.
  • To synthesize current knowledge on GH-GHR's role in different cancer types.
  • To explore therapeutic implications of targeting the GH-GHR pathway in cancer.

Main Methods:

  • Literature review of in vitro, in vivo, and epidemiological studies.
  • Analysis of molecular mechanisms underlying GH-GHR action in cancer.
  • Synthesis of data on therapy resistance mediated by GH-GHR.

Main Results:

  • GH-GHR signaling contributes to therapy resistance in multiple cancer types.
  • Specific molecular pathways affected by GH-GHR in cancer prognosis are identified.
  • Evidence suggests GH-GHR as a potential therapeutic target.

Conclusions:

  • GH-GHR signaling is a significant factor in cancer therapy resistance.
  • Targeting the GH-GHR axis may offer novel therapeutic strategies for cancer treatment.
  • Further research is needed to fully elucidate and exploit GH-GHR's role in oncology.
Keywords:
Growth hormone receptorchemoresistancegrowth hormonetherapy resistance

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