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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.

E I Ustyantseva1,2, S P Medvedev1,2, S M Zakian3,4

  • 1Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.

Advances in Experimental Medicine and Biology
|May 9, 2020
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. This review explores complex ALS molecular pathology and novel research methods, discussing current and potential treatments for improved therapeutic outcomes.

Keywords:
ALSAmyotrophic lateral sclerosisDisease mechanisms

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Area of Science:

  • Neuroscience
  • Neurology
  • Genetics

Background:

  • Amyotrophic lateral sclerosis (ALS) is a common, progressive neurodegenerative disease leading to paralysis.
  • Current treatments for ALS offer only modest benefits, highlighting a need for better therapeutic strategies.
  • Understanding the complex molecular pathology of ALS is crucial for developing effective interventions.

Purpose of the Study:

  • To review current knowledge on ALS molecular pathology.
  • To highlight novel research methodologies applied to ALS studies.
  • To discuss existing and potential therapeutic strategies based on recent findings.

Main Methods:

  • Literature review of scientific publications on ALS.
  • Analysis of molecular pathology mechanisms in ALS.
  • Evaluation of current and emerging treatment strategies.

Main Results:

  • The review summarizes key molecular pathways implicated in ALS initiation and progression.
  • Novel research methods offer more accurate insights into ALS pathology compared to traditional models.
  • Current therapeutic options for ALS are limited, with modest efficacy.

Conclusions:

  • A deeper understanding of ALS molecular pathology is essential for advancing treatment.
  • Novel research approaches are critical for overcoming limitations of traditional models.
  • Future therapeutic strategies should leverage recent findings in ALS disease mechanisms for greater impact.