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Sustained subconjunctival drug delivery systems: current trends and future perspectives
Fojan Rafiei1, Hadi Tabesh2, Farrokh Farzad3
1Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
International Ophthalmology
|May 9, 2020
Summary
Subconjunctival drug delivery offers a less invasive and accessible method for treating eye conditions. This periocular route effectively delivers drugs to both anterior and posterior eye segments, showing promise for various ocular diseases.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Drug Delivery Systems
Background:
- Sustainable ocular drug delivery to the posterior eye segment remains a significant challenge.
- Periocular routes are emerging as a promising solution for overcoming these delivery hurdles.
Purpose of the Study:
- To review recent advancements in subconjunctival drug delivery.
- To compare the advantages and disadvantages of the subconjunctival route with other ocular delivery methods.
Main Methods:
- A comprehensive literature search was conducted using MEDLINE/PubMed.
- Relevant keywords were used to identify studies on subconjunctival drug delivery systems.
Main Results:
- Many current ocular delivery routes are highly invasive or offer low drug bioavailability.
- Subconjunctival delivery is less invasive, easily accessible, and suitable for both anterior and posterior eye segments.
- Most research in this area is currently in the animal study phase.
Conclusions:
- Periocular routes, particularly subconjunctival delivery, are efficient for drug administration to all eye segments.
- Subconjunctival sustained drug delivery (implants/injections) is highly effective and less invasive than other periocular options.
- This method shows potential for treating diverse ocular diseases like diabetic retinopathy, dry eye, and glaucoma.
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