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Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer

Nima Hemmat1,2, Ahad Mokhtarzadeh1, Mohammad Aghazadeh3,4

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Molecular Biology Reports
|May 9, 2020
PubMed

Insights

This review highlights microRNAs (miRNAs) involved in cervical cancer progression. These miRNAs target genes within the epidermal growth factor receptor (EGFR) signaling pathway, driving cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cervical cancer is a prevalent malignancy in women globally.
  • Signaling pathways like ERK/MAPK, PI3K/AKT, and epidermal growth factor receptor (EGFR) are implicated in its progression.
  • MicroRNAs (miRNAs) play a crucial role in regulating gene expression in various cancers, including cervical cancer.

Purpose of the Study:

  • To review and highlight microRNAs (miRNAs) implicated in cervical cancer.
  • To elucidate the role of miRNA targets within the epidermal growth factor receptor (EGFR) signaling pathway in cervical cancer progression.
  • To identify potential miRNA candidates targeting differentially expressed genes in the EGFR pathway in cervical cancer.

Main Methods:

  • Literature review of Scopus, PubMed, and Google Scholar databases to identify relevant miRNAs and their targets in cervical cancer.
  • Utilized miRWalk 3.0 and TargetScan 7.1 for predicting miRNA interactions with differentially expressed genes in the EGFR signaling pathway.
  • Analyzed microarray data from NCBI Gene Expression Omnibus (GEO) datasets for cervical cancer.

Main Results:

  • Several microRNAs (miRNAs) and their target genes involved in cervical cancer were identified.
  • A subset of these miRNA targets were found to be members of the epidermal growth factor receptor (EGFR) signaling pathway.
  • Predicted miRNAs showed interactions with differentially expressed genes within the EGFR pathway in cervical cancer samples compared to normal samples.

Conclusions:

  • MicroRNAs play a significant role in cervical cancer by regulating the epidermal growth factor receptor (EGFR) signaling pathway.
  • Targeting specific miRNAs could offer a novel therapeutic strategy for cervical cancer by modulating the EGFR pathway.
  • Further research is warranted to validate the identified miRNA-EGFR pathway interactions and their clinical relevance.
Keywords:
Cervical cancerEpidermal growth factor receptorErbB family kinase receptorsMicroRNAs

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