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Cancer incidence in Behçet's disease
Deniz Can Guven1, Ertugrul Cagri Bolek2, Sabri Engin Altintop3
1Department of Medical Oncology, Hacettepe University Cancer Institute, 06100 Sıhhıye, Ankara, Turkey. denizcguven@hotmail.com.
Irish Journal of Medical Science
|May 9, 2020
Summary
Patients with Behçet's disease (BD) face nearly triple the cancer risk compared to the general population. Increased cancer surveillance is crucial for BD patients during routine follow-up care.
Area of Science:
- Rheumatology
- Oncology
- Epidemiology
Background:
- Autoimmune diseases are linked to elevated cancer risk.
- Limited data suggests Behçet's disease (BD) may also increase cancer risk.
Purpose of the Study:
- To assess cancer incidence in a large cohort of Behçet's disease patients.
- To compare cancer risk in BD patients with age- and gender-matched general population data.
Main Methods:
- A prospective cohort study of 451 adult BD patients.
- Cancer incidence was compared to the 2014 Turkish National Cancer Registry using standardized incidence rates (SIR).
Main Results:
- BD patients exhibited a significantly increased cancer risk (SIR 2.84, p < 0.001).
- A trend towards decreased cancer risk was observed in patients with papulopustular lesions (p=0.060).
- Azathioprine use was associated with a significantly decreased cancer risk (p=0.031).
Conclusions:
- Behçet's disease patients have approximately a threefold higher cancer risk.
- Enhanced cancer surveillance is recommended for BD patients beyond routine care.
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