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Related Experiment Videos

Evolution of the rheumatoid factor over time.

S Ferri1, L Favaro, B Facchini

  • 1Rheumatology Unit of Policlinico S. Orsola-Malpighi, Bologna, Italy.

Scandinavian Journal of Rheumatology. Supplement
|January 1, 1988
PubMed
Summary
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Rheumatoid Factor (RF) levels fluctuate in rheumatoid arthritis (RA) patients over time. While some RA patients show decreasing RF positivity, healthy individuals may increase RF positivity, impacting diagnostic value.

Area of Science:

  • Immunology
  • Rheumatology
  • Epidemiology

Background:

  • Rheumatoid Factor (RF) is a key biomarker in rheumatoid arthritis (RA).
  • Understanding RF's longitudinal behavior is crucial for its epidemiological and diagnostic value.
  • Variations in RF testing methods may influence results.

Purpose of the Study:

  • To assess the epidemiological significance of Rheumatoid Factor (RF) variations over time in rheumatoid arthritis (RA).
  • To analyze RF test result trends in RA patients and healthy controls.
  • To evaluate the stability of RF profiles in different patient groups.

Main Methods:

  • Longitudinal study of 421 RA patients (Group A) and 348 RA patients with 48-month follow-up (Group B).
  • Cross-sectional study of 750 healthy individuals (Group C) with 48-month follow-up.

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  • Utilized five agglutination tests for RF detection, including latex, red blood cells (slide and tube).

    • Main Results:

    • Group A showed uneven variations in positive RF results.
    • Group B demonstrated maximum RF profile confirmation in short-term follow-up, with decreasing confirmation rates later, except for consistently negative tests.
    • Group C exhibited varying positive frequencies across tests, with an overall increase in positive results over 4 years.

    Conclusions:

    • Serum-positive RA patients tend to decrease RF positivity over time.
    • Healthy individuals with initially few positive RF tests may increase positivity over time.
    • RA patients with consistently negative RF tests maintain a stable profile.