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Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes
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Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart

Marisol Ruiz-Meana1, Diana Bou-Teen1, Péter Ferdinandy2,3

  • 1Department of Cardiology, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autonoma de Barcelona and Centro de Investigación Biomédica en Red-CV, CIBER-CV, Madrid, Spain.

Cardiovascular Research
|May 9, 2020
PubMed

Insights

Advanced age increases heart disease risk and impairs recovery from ischemia/reperfusion injury by altering cellular pathways. Understanding cardiac aging pathophysiology is crucial for improving cardioprotective strategies in older adults.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Molecular Cardiology

Background:

  • Advanced age is a significant risk factor for coronary syndromes and heart failure.
  • Aging impacts the heart's response to cardioprotective interventions and increases susceptibility to ischemia/reperfusion (IR) injury.
  • Age-related changes include defective or attenuated signaling pathways and exacerbated detrimental pathways like glycoxidation and inflammation.

Purpose of the Study:

  • To review current knowledge on the pathophysiology of cardiac aging.
  • To elucidate how cardiac aging affects cellular susceptibility to IR injury.
  • To discuss the impact of aging on the efficacy of cardioprotective strategies.

Main Methods:

  • Literature review of current research on cardiac aging and IR injury.
  • Analysis of age-related changes in cellular signaling pathways.
  • Examination of the interplay between aging, IR injury, and cardioprotection.

Main Results:

  • Aging exacerbates adverse post-ischemic remodeling and heart failure risk.
  • Specific signaling pathways are dysregulated during aging, affecting cellular response to IR.
  • Detrimental pathways (glycoxidation, inflammation) are amplified with age.

Conclusions:

  • Cardiac aging significantly predisposes the heart to IR injury and adverse outcomes.
  • Understanding the molecular mechanisms of cardiac aging is essential for developing effective cardioprotective therapies for the elderly.
  • Further research is needed to fully elucidate the causative mechanisms of age-related cardiac dysfunction.

Keywords:
Animal modelsCardiac ageingCardioprotectionIschaemia/reperfusion injuryOmics

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