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Individualized Treatment of Multidrug-resistant Tuberculosis Using Whole-Genome Sequencing and Expanded
Navisha Dookie1,2, Nesri Padayatchi1,2, Richard J Lessells1,3
1Centre for the AIDS Programme of Research in South Africa (CAPRISA), Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal Durban, South Africa.
Abstract:
A case of multidrug-resistant tuberculosis is presented. It highlights the role of whole-genome sequencing, expanded phenotypic drug susceptibility testing, and enhanced case management, offering a more complete understanding of drug susceptibility to Mycobacterium tuberculosis. This approach guides an effective individualized treatment strategy that results in rapid sustained culture conversion.
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