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COVID-19 in Neonates and Infants: Progression and Recovery

Khuen Foong Ng1, Srini Bandi1, Paul William Bird2

  • 1From the Paediatric Department, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

The Pediatric Infectious Disease Journal
|May 9, 2020
PubMed

Insights

In a study of infants with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), most presented with fever and respiratory symptoms. Fortunately, all infants recovered and were discharged home well.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • The early 2020 COVID-19 pandemic prompted investigation into pediatric SARS-CoV-2 infections.
  • Understanding the clinical presentation and outcomes in infants is crucial for effective management.

Purpose of the Study:

  • To describe the clinical characteristics and outcomes of infants diagnosed with SARS-CoV-2.
  • To identify common symptoms and complications in this pediatric population.

Main Methods:

  • Retrospective review of infants diagnosed with SARS-CoV-2 between March 10 and April 17, 2020.
  • Analysis of presenting symptoms, laboratory findings, treatments, and patient disposition.

Main Results:

  • 11.4% of presented infants tested positive for SARS-CoV-2.
  • Common symptoms included fever (63%) and lower respiratory tract involvement (50%).
  • Some infants experienced neutropenia and thrombocytosis (25%), with 50% treated for suspected sepsis.

Conclusions:

  • While some infants exhibited significant symptoms and required antibiotic treatment for suspected sepsis, severe outcomes were uncommon.
  • The majority of SARS-CoV-2 positive infants in this cohort experienced a favorable clinical course with full recovery.

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