Maresin 1 Promotes Wound Healing and Socket Bone Regeneration for Alveolar Ridge Preservation.

Area of Science:

• Biomedical Engineering
• Oral and Maxillofacial Surgery
• Regenerative Medicine

Background:

• Tooth extraction causes alveolar bone loss and post-operative pain.
• Maresin 1 (MaR1) is a lipid mediator that resolves inflammation and promotes tissue regeneration.
• Accelerating socket healing is crucial for successful dental implant procedures.

Purpose of the Study:

• To investigate the efficacy of Maresin 1 (MaR1) in promoting tooth extraction socket wound healing.
• To evaluate MaR1's impact on bone regeneration and pain reduction in a preclinical rat model.

Main Methods:

• Extraction of maxillary first molars in Sprague-Dawley rats.
• Application of gelatin scaffolds with or without MaR1 into extraction sockets.
• Assessment of pain, histology, microcomputed tomography, and macrophage populations (CD206+/CD68+).

Main Results:

• MaR1 significantly accelerated soft tissue healing and re-epithelialization.
• MaR1 (0.05 μg/μL) enhanced bone fill by day 10 and preserved alveolar ridge dimensions by day 21.
• MaR1 treatment reduced post-operative pain scores and increased the CD206+:CD68+ macrophage ratio.

Conclusions:

• Local MaR1 administration effectively accelerates extraction socket healing and bone regeneration.
• MaR1 preserves alveolar bone structure and mitigates post-operative pain.
• MaR1 shows significant clinical potential for improving outcomes in dental implant reconstruction.