[Methods for Creating Medium and Large Animal Models of Peripheral Atherosclerosis]

Area of Science:

• Cardiovascular Research
• Animal Modeling

Background:

• Atherosclerosis (AS) is a primary cause of vascular diseases and linked to metabolic syndrome.
• Peripheral arterial diseases due to AS have high morbidity and mortality with limited effective treatments.
• Developing effective animal models is crucial for advancing AS research and treatment.

Purpose of the Study:

• To elucidate current methods for creating medium and large animal models of peripheral atherosclerotic disease.
• To facilitate the clinical translation of atherosclerosis treatment research.

Main Methods:

• Review of existing literature on atherosclerosis (AS) animal model creation.
• Focus on techniques applicable to medium and large animal models.
• Discussion of methods for inducing peripheral arterial disease in animal models.

Main Results:

• Established small and medium AS animal models using high-fat diets and balloon injuries.
• Identified a gap in literature regarding the creation of large animal models for AS treatment.
• Outlined current methodologies for developing medium and large animal models for peripheral AS.

Conclusions:

• Current methods for creating medium and large animal models of peripheral atherosclerotic disease are discussed.
• The development of these models is essential for promoting clinical translation of AS treatments.
• Further research into large animal models is needed to improve therapeutic strategies for AS-related diseases.