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Updated: Dec 22, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications' door

Francesco Talotta1,2, Laura Casalino1, Pasquale Verde3

  • 1Institute of Genetics and Biophysics "Adriano Buzzati Traverso" CNR, Naples, Italy.

Oncogene
|May 10, 2020
PubMed

Insights

The transcription factor Fra-1 (encoded by FOSL1) drives human tumor progression and metastasis. This review explores FOSL1

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Fra-1 (FOSL1) is a key transcription factor in the AP-1 complex implicated in human cancer.
  • Understanding Fra-1's role is critical for developing targeted cancer therapies.

Purpose of the Study:

  • To provide a comprehensive review of the current knowledge on FOSL1 and its gene product, Fra-1.
  • To discuss emerging topics, therapeutic strategies, and Fra-1's role in cancer progression and treatment resistance.

Main Methods:

  • Literature review summarizing existing research on FOSL1.
  • Analysis of transcriptional, epigenetic, and post-translational regulation of Fra-1.
  • Examination of Fra-1's role in gene networks, tumor microenvironment, and therapeutic resistance.

Main Results:

  • FOSL1 controls Fra-1 accumulation through transcriptional and epigenetic mechanisms in various solid tumors.
  • Fra-1 influences proliferation, survival, epithelial-mesenchymal transitions (EMT), and the tumor microenvironment.
  • Fra-1 signatures have prognostic value and Fra-1 is involved in resistance and addiction to targeted therapies.

Conclusions:

  • Fra-1 is a significant driver of tumor progression, metastasis, and therapeutic resistance.
  • Targeting FOSL1 presents a promising therapeutic avenue for various human cancers.
  • Further research into Fra-1 regulation and function is warranted for effective cancer treatment strategies.

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