Marginal zone lymphoma associated amyloidosis: A case report and literature review

The marginal zone lymphoma is a common indolent malignant tumor in the blood system, but the patients with myocardial amyloidosis is rare. In January 2018,a marginal zone lymphoma associated with myocardial amyloidosis was accepted by the Third Xiangya Hospital, Central South University, main complaining of shortness of breath for more than half a year.The patient manifested with multiple serous effusion, positive for IgM κ-type M protein, and myocardial amyloidosis. Bone marrow puncture suggested as mature small lymphocyte proliferative disease, and the bone marrow biopsy eventually diagnosed as marginal zone lymphoma involving the bone marrow. The treatment of this disease includes rituzumab, radiochemotherapy and hematopoietic stem cell transplantation.Due to the lack of sepcificity in sympotoms,it is necessary to rely on histopathological biopsy and immunohistochemistry to confirm the diagnosis. The disease is easily missed or misdiagnosed and the prognosis is poor.