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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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Feline Neuropathic Pain.

Mark E Epstein1

  • 1TotalBond Veterinary Hospital, c/o Forestbrook, 3200 Union Road, Gastonia, NC 28056, USA.

The Veterinary Clinics of North America. Small Animal Practice
|May 11, 2020
PubMed
Summary

Feline neuropathic pain, a disease of exaggerated pain processing, is an underdiagnosed cause of significant morbidity in cats. This article reviews its mechanisms, recognition, and treatment.

Keywords:
FelineHypersensitizationMaladaptiveNeuropathic painNeuroplasticityPeripheral/Central nervous systemSensitizationWindup

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Area of Science:

  • Veterinary Neurology
  • Pain Management
  • Animal Health

Background:

  • Neuropathic pain is a severe form of maladaptive pain processing.
  • It is a disease characterized by exaggerated pain in various aspects like severity, duration, and spontaneity.
  • This condition is likely underdiagnosed and underappreciated in feline patients, contributing to significant morbidity.

Purpose of the Study:

  • To explore the fundamental mechanisms of neuropathic pain in cats.
  • To discuss the recognition and diagnosis of feline neuropathic pain.
  • To review known and suspected syndromes and prospective treatments for feline maladaptive and neuropathic pain.

Main Methods:

  • Literature review of neuropathic pain mechanisms.
  • Analysis of clinical signs and diagnostic approaches for feline pain.
  • Synthesis of current and emerging treatment strategies for neuropathic pain in cats.

Main Results:

  • Neuropathic pain in cats involves complex maladaptive pain processing.
  • Early recognition and accurate diagnosis are crucial for effective management.
  • A range of therapeutic options, though often requiring multimodal approaches, are available or under investigation.

Conclusions:

  • Feline neuropathic pain is a distinct disease entity requiring specific diagnostic and therapeutic considerations.
  • Increased awareness and understanding are needed to address this underdiagnosed condition.
  • Further research into feline neuropathic pain mechanisms and treatments is warranted.