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Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

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Related Experiment Video

Updated: Dec 22, 2025

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

The Biofilms Structural Database.

Rita P Magalhães¹, Tatiana F Vieira¹, Henrique S Fernandes¹

¹UCIBIO/REQUIMTE, BioSIM, Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.

Trends in Biotechnology

|May 11, 2020

Summary

This summary is machine-generated.

The Biofilms Structural Database (BSD) offers curated data on protein structures and enzymes crucial for bacterial biofilm formation. This resource aids researchers in understanding and combating biofilms across various bacterial species.

Keywords:

antimicrobials bacteria inhibition quorum sensing resistance

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Last Updated: Dec 22, 2025

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

An Analytical Tool-box for Comprehensive Biochemical, Structural and Transcriptome Evaluation of Oral Biofilms Mediated by Mutans Streptococci

Published on: January 25, 2011

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Published on: December 27, 2016

Area of Science:

Microbiology
Structural Biology
Bioinformatics

Background:

Bacterial biofilms are complex communities that contribute to persistent infections and antimicrobial resistance.
Understanding the molecular mechanisms of biofilm formation is critical for developing novel therapeutic strategies.
Existing databases may lack comprehensive structural and functional data related to biofilm development.

Purpose of the Study:

To establish a centralized repository of structural, mutagenesis, kinetics, and inhibition data relevant to biofilm formation.
To provide a valuable resource for researchers investigating the molecular basis of bacterial biofilms.
To facilitate the discovery of new targets for anti-biofilm interventions.

Main Methods:

Curated data collection from scientific literature and structural databases.
Inclusion of information on protein structures, mutagenesis, kinetics, and inhibition data.
Organization of data by bacterial species and relevant proteins/enzymes.

Main Results:

The Biofilms Structural Database (BSD) currently contains data for 425 structures.
Information covers proteins and enzymes involved in biofilm formation and development.
Data spans 42 different bacterial species, highlighting the broad applicability of the database.

Conclusions:

The BSD serves as a comprehensive resource for studying biofilm formation.
This database can accelerate research into the structural and functional aspects of biofilm-related proteins.
Accessibility via www.biofilms.biosim.pt promotes wider use in the scientific community.