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Identification of new arylsulfide derivatives as anti-melanogenic agents in a zebrafish model
Se Hwan Ahn1, Kyu-Seok Hwang2, Dae-Seop Shin2
1Department of Chemistry, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
Bioorganic & Medicinal Chemistry Letters
|May 11, 2020
Abstract:
A series of aryl sulfide derivatives was synthesized and evaluated for their anti-melanogenic activities. Several compounds, including 3e, 3i and 3q exhibited good anti-melanogenic activities. Among the derivatives, compound 3i showed good inhibitory effects against melanin synthesis and showed no toxicity in reconstituted human eye and skin tissues.
