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Histological analysis of socket preservation using DBBM. A systematic review and meta-analysis
1Multi-disciplinary Treatment Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Tian Tan Xi Li Number.4, 100050 Beijing, China; Department of Periodontology, Witten/Herdecke, University, Alfred-Herrhausen-Str. 45, 58445 Witten, Germany.
Summary
Deproteinized bovine bone mineral (DBBM) site preservation after tooth extraction showed less new bone formation than natural healing. DBBM offers no added benefit for postextraction socket preservation regarding bone growth.
Area of Science:
- Biomaterials Science
- Oral and Maxillofacial Surgery
- Regenerative Medicine
Background:
- Deproteinized bovine bone mineral (DBBM) is a common bone substitute for tooth extraction sites.
- Evidence for DBBM's efficacy in promoting new bone formation during socket preservation is limited.
- This study addresses the need for evidence regarding DBBM's role in postextraction site preservation.
Purpose of the Study:
- To systematically review and meta-analyze the effectiveness of DBBM for postextraction socket preservation.
- To compare new bone formation in sites preserved with DBBM versus natural healing.
- To evaluate the impact of DBBM on connective tissue percentage in extraction sockets.
Main Methods:
- A systematic review and meta-analysis of histological results from postextraction socket preservation studies.
- Searched three databases for studies published between 2000 and 2019.
- Included five studies that reported histological outcomes for DBBM and natural healing groups.
Main Results:
- The DBBM group exhibited significantly lower new bone percentage (-24.75%) compared to natural healing (P=0.001).
- No significant difference was found in the percentage of connective tissue between the DBBM and natural healing groups (P=0.83).
- The meta-analysis indicated that DBBM did not enhance new bone formation in socket preservation.
Conclusions:
- Site preservation using DBBM provides no additional benefit for postextraction new bone formation compared to natural healing.
- Current evidence suggests DBBM is not superior to natural healing for this application.
- Further high-quality, large-sample studies are required to confirm these findings and guide clinical practice.
