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Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

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Impact of Histopathological Prostate Inflammation on Urine-Based Prostate Cancer Prediction Using the Prostate Cancer

Jörg Hennenlotter¹, Tim Neumann¹, Sven Perner^2,3

¹Department of Urology, Eberhard Karls University of Tübingen, Tübingen, Germany.

Urologia Internationalis

|May 11, 2020

Summary

Prostate cancer (PC) gene 3 (PCA3) scores decrease with inflammation. This finding is crucial for interpreting PCA3 test results, especially after recent biopsies, as inflammation impacts prostate cancer diagnostics.

Keywords:

Diagnostics Histological inflammation Prostate Cancer gene 3 assay Prostate cancer Urine marker

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Area of Science:

Urology
Oncology
Molecular Diagnostics

Background:

The Prostate Cancer gene 3 (PCA3) urine test is increasingly used for prostate cancer (PC) diagnosis.
Previous research suggested PCA3 is unaffected by inflammation, but evidence was limited.

Purpose of the Study:

To investigate the effect of histological inflammation on PCA3 scores.
To determine if inflammation influences the accuracy of PCA3 testing for prostate cancer.

Main Methods:

PCA3 scores were measured in patients before prostate biopsy and radical prostatectomy.
Inflammation was assessed and quantified in patients without PC.
Univariate and multivariate analyses examined the relationship between inflammation and PCA3 scores.

Main Results:

PCA3 scores were lower before prostatectomy compared to before positive biopsy.
A significant proportion of negative biopsies (78%) showed inflammation.
PCA3 scores decreased progressively with increasing grade and extent of inflammation (p=0.016).

Conclusions:

PCA3 scores are reduced in the presence of inflammation.
Inflammation is a significant factor influencing PCA3 test results, particularly after recent biopsies.
Inflammation should be considered when interpreting PCA3 and other prostate cancer diagnostic tests.