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Updated: Dec 21, 2025
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin - An experimental
M-Á Sánchez-Garcés1, O Camps-Font, J Escoda-Francolí
1School of Medicine and Health Sciences Campus de Bellvitge, University of Barcelona Pavelló Govern, 2ª planta, Despatx 2.9, C/ Feixa Llarga, s/n 08907, L'Hospitalet de Llobregat, Barcelona, Spain ocamps@ub.edu.
Background:
The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope.
Material And Methods:
CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS).
Results:
60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056).
Conclusions:
Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs.
