Related Experiment Video
Updated: Dec 21, 2025
08:23
Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
Published on: March 13, 2012
60.3K
HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice.
Farhana Sakloth1, Lefteris Manouras1, Kleopatra Avrampou1
1Nash Family Department of Neuroscience, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, Box 10-65, New York, NY, 10029, USA.
Psychopharmacology
|May 11, 2020
Summary
Novel HDAC6 inhibitors, ACY-738 and ACY-257, effectively reduced pain hypersensitivity in mouse models of nerve injury and inflammation. These findings suggest HDAC6 inhibition as a promising strategy for pain relief.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Histone deacetylase 6 (HDAC6) is implicated in pain pathways.
- Novel selective HDAC6 inhibitors were investigated for therapeutic potential.
Purpose of the Study:
- To evaluate the efficacy of HDAC6 inhibitors in alleviating pain behaviors.
- To assess the therapeutic potential of HDAC6 inhibition for nerve injury and inflammation-induced pain.
Main Methods:
- Murine spared nerve injury (SNI) and Complete Freund's Adjuvant (CFA) models were used.
- Mechanical allodynia was measured using the Von Frey assay.
Main Results:
- Brain-penetrant ACY-738 abolished mechanical allodynia in SNI mice (male and female) without tolerance.
- Non-brain-penetrant ACY-257 also showed antiallodynic effects in SNI and CFA models.
- Both compounds attenuated mechanical allodynia in CFA-induced peripheral inflammation.
Conclusions:
- HDAC6 inhibition demonstrates significant potential for treating pain associated with peripheral nerve injury.
- HDAC6 inhibition offers a promising therapeutic approach for managing pain from peripheral inflammation.
