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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Beyond skin deep: addressing comorbidities in psoriasis.

Tom Kovitwanichkanont1, Alvin H Chong1,2, Peter Foley1,2

  • 1Skin Health Institute, Melbourne, VIC.

The Medical Journal of Australia
|May 11, 2020
PubMed
Summary

Psoriasis is a chronic inflammatory disease linked to numerous comorbidities, impacting overall health and quality of life. Early recognition and management of these associated conditions, alongside lifestyle changes, are crucial for better patient outcomes.

Keywords:
ComorbiditiesImmunosuppressionPrimary carePsoriasisSkin diseases

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Area of Science:

  • Dermatology
  • Immunology
  • Public Health

Background:

  • Psoriasis is a chronic inflammatory skin condition with systemic implications.
  • It is associated with significant comorbidities including psoriatic arthritis, cardiovascular disease, mental health disorders, and increased malignancy risk.
  • These comorbidities contribute to reduced quality of life and life expectancy.

Purpose of the Study:

  • To highlight the systemic nature of psoriasis and its associated comorbidities.
  • To emphasize the importance of recognizing and screening for these comorbidities in primary care.
  • To underscore the benefits of tailored management strategies and modifiable risk factor reduction.

Main Methods:

  • Review of current literature on psoriasis and its comorbidities.
  • Analysis of risk factors associated with disease severity and psoriatic arthritis.
  • Discussion of available therapeutic options and lifestyle interventions.

Main Results:

  • Psoriasis is linked to elevated risks of psoriatic arthritis, cardiovascular disease, obesity, mental health disorders, malignancy, and other immune-related conditions.
  • Psoriatic nail involvement, severe skin disease, and obesity increase the risk of psoriatic arthritis.
  • Cardiovascular disease and malignancy are leading causes of reduced life expectancy in psoriasis patients.

Conclusions:

  • Early recognition and management of psoriasis comorbidities are essential for improving patient prognosis and quality of life.
  • Routine screening for psoriatic arthritis is recommended for individuals with psoriasis.
  • Smoking cessation and limiting alcohol intake are critical modifiable risk factors for psoriasis management.