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The WWOX gene in brain development and pathology
K Kośla1, Ż Kałuzińska1, A K Bednarek1
1Department of Molecular Carcinogenesis, Medical University of Lodz, Lodz 90-752, Poland.
Experimental Biology and Medicine (Maywood, N.J.)
|May 12, 2020
Summary
The WWOX gene regulates cell processes including tumor suppression and nervous system development. This review details its crucial roles in central nervous system (CNS) development and function.
Area of Science:
- Molecular Biology
- Neuroscience
- Genetics
Background:
- The WW domain-containing oxidoreductase (WWOX) gene is vital for cellular functions.
- WWOX acts as a transcription regulator in processes like tumor suppression and apoptosis.
- Its role in central nervous system (CNS) development is increasingly recognized.
Purpose of the Study:
- To comprehensively review the known functions of the WWOX gene.
- To discuss the significance of WWOX in CNS development and functioning.
Main Methods:
- Literature review of existing studies on WWOX.
- Synthesis of current knowledge on WWOX gene functions.
Main Results:
- WWOX is implicated in tumor suppression, cell proliferation, and apoptosis.
- It plays a critical role in steroid metabolism.
- WWOX is essential for normal CNS development and ongoing function.
Conclusions:
- The WWOX gene is a multifunctional protein with significant implications for human health.
- Understanding WWOX's role is crucial for advancing research in CNS disorders and cancer therapy.
Keywords:
WW domain-containing oxidoreductaseWWOXglioblastomainfantile encephalopathyneurodegenerationneurodifferentiationneurogenesisMore Related Videos
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