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Published on: September 22, 2023
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Phenotypes of Chronic Rhinosinusitis
Seong H Cho1, Daniel L Hamilos2, Doo Hee Han3
1Division of Allergy-Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Fla.
Summary
Chronic rhinosinusitis (CRS) is a complex disease with diverse phenotypes and endotypes. Understanding these endotypes is key to developing precise, personalized biologic treatments for CRS management.
Area of Science:
- Otolaryngology
- Immunology
- Pulmonology
Background:
- Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory airway disease.
- Recent advances in understanding CRS endotypes have enabled targeted biologic therapies.
- Current CRS classification relies on phenotypes (e.g., with/without nasal polyps), which do not fully capture underlying endotypes.
Purpose of the Study:
- To review diagnostic approaches for various CRS phenotypes.
- To outline current treatment strategies for distinct CRS phenotypes.
- To emphasize the link between endotype understanding and personalized CRS treatment.
Main Methods:
- Literature review of diagnostic methods for CRS phenotypes.
- Synthesis of current therapeutic guidelines for CRS management.
- Analysis of the relationship between CRS endotypes and clinical presentation.
Main Results:
- CRS presents with diverse phenotypes including fungal, infectious, AERD, CF, pediatric, and systemic disease-associated forms.
- Biologic agents offer effective management for specific CRS endotypes.
- A phenotype-based classification, while simple, requires integration with endotype data for precision.
Conclusions:
- A deeper understanding of CRS endotypes is crucial for refining phenotype classification.
- Personalized treatment strategies based on endotype identification promise improved CRS management outcomes.
- Integrating diagnostic and therapeutic advances will lead to more scientific and precise patient care.
Keywords:
AERDAspirin-exacerbated respiratory diseaseChronic rhinosinusitisCystic fibrosisFungal rhinosinusitisNasal polypsMore Related Videos
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