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Updated: Dec 21, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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The cross-talk of NOTCH and GSK-3 signaling in colon and other cancers

Fred E Bertrand1

  • 1Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Biochimica Et Biophysica Acta. Molecular Cell Research
|May 12, 2020
PubMed

Insights

Glycogen synthase kinase-3 beta (GSK-3β) and Notch signaling pathways interact to drive cancer development. This review highlights their crosstalk in colon cancer oncogenesis.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncology

Background:

  • Glycogen synthase kinase-3 (GSK-3) kinases, including GSK-3α and GSK-3β, regulate crucial cellular processes like cell proliferation and apoptosis.
  • GSK-3β is implicated in various cancers through its involvement in the PTEN/PI3K/AKT and RAS/RAF/MEK/ERK signaling pathways.
  • Notch receptor signaling is vital for cell fate determination and can promote oncogenesis when dysregulated.

Purpose of the Study:

  • To review the intricate crosstalk between GSK-3β and Notch signaling pathways.
  • To elucidate how this crosstalk contributes to oncogenesis, with a specific focus on colon cancer.

Main Methods:

  • Literature review of studies investigating GSK-3β and Notch signaling.
  • Analysis of shared targets and regulatory interactions between the two pathways.
  • Examination of their roles in oncogenic processes, particularly in colon cancer.

Main Results:

  • GSK-3β and Notch signaling pathways share common targets, including β-catenin and the WNT pathway.
  • Both pathways are involved in critical oncogenic processes, notably in colon cancer.
  • Evidence suggests GSK-3β may directly influence Notch signaling, creating a synergistic effect in cancer promotion.

Conclusions:

  • The interplay between GSK-3β and Notch signaling represents a significant mechanism driving oncogenesis.
  • Targeting the crosstalk between GSK-3β and Notch may offer novel therapeutic strategies for cancers like colon cancer.
Keywords:
InflammationNotchObesityOncogenesisStem cellWnt

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