Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

8.5K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
8.5K
Overview of the Heart01:07

Overview of the Heart

12.2K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
12.2K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

1.3K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
1.3K
Heart Valves01:16

Heart Valves

10.4K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
10.4K
Anatomy of the Heart01:27

Anatomy of the Heart

118.5K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
118.5K
Anatomy of the Heart01:20

Anatomy of the Heart

2.0K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevated mitochondrial Ca<sup>2+</sup> impairs satellite cell pool expansion in response to skeletal muscle injury.

Stem cell reports·2026
Same author

Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.

Circulation research·2025
Same author

Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.

bioRxiv : the preprint server for biology·2025
Same author

Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury.

The Journal of physiology·2025
Same author

MICUs protect the heart by regulating mitochondrial calcium.

Trends in pharmacological sciences·2024
Same author

MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.

Circulation research·2024
Same journal

Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction.

Journal of molecular and cellular cardiology·2026
Same journal

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension.

Journal of molecular and cellular cardiology·2026
Same journal

Therapeutic impact of normal dietary patterns on diabetic cardiomyopathy: Transcriptomic and proteomic insights.

Journal of molecular and cellular cardiology·2026
Same journal

Structural, biophysical and cellular assessment of filamin C M82K: A test case for VUS interpretation in cardiomyopathy.

Journal of molecular and cellular cardiology·2026
Same journal

Precision modification of heart failure signaling by CRISPR-Cas9 base editing.

Journal of molecular and cellular cardiology·2026
Same journal

Retraction notice to 'Sam68 impedes the recovery of arterial injury by augmenting inflammatory response' [Journal of Molecular and Cellular Cardiology 137 (2019) 82-92].

Journal of molecular and cellular cardiology·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

11.3K

Is MCU dispensable for normal heart function?

Julia C Liu1

  • 1Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Journal of Molecular and Cellular Cardiology
|May 12, 2020
PubMed
Summary
This summary is machine-generated.

Mitochondrial calcium uptake is vital for energy but overload causes cell death. Recent discoveries reveal the proteins of the mitochondrial calcium uniporter, impacting heart function.

More Related Videos

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes
06:25

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes

Published on: November 11, 2022

3.7K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.5K

Related Experiment Videos

Last Updated: Dec 21, 2025

Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

11.3K
A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes
06:25

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes

Published on: November 11, 2022

3.7K
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
07:51

Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

Published on: February 17, 2023

1.5K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Mitochondrial calcium (Ca2+) uptake signals energy needs but overload triggers cell death via the mitochondrial permeability transition pore.
  • The mitochondrial calcium uniporter regulates Ca2+ entry into mitochondria, balancing energy production and cell survival.

Purpose of the Study:

  • To review recent findings on the molecular components of the mitochondrial calcium uniporter.
  • To discuss the impact of uniporter protein disruption on mitochondrial Ca2+ regulation and tissue function, with a focus on the heart.

Main Methods:

  • Literature review of studies in cultured cells and animal models.
  • Analysis of research on the molecular identities and functions of uniporter proteins.

Main Results:

  • Significant progress in identifying the multiple proteins that constitute the mitochondrial calcium uniporter.
  • Evidence linking uniporter protein function to mitochondrial Ca2+ homeostasis and physiological outcomes in various tissues.

Conclusions:

  • Understanding the mitochondrial calcium uniporter is crucial for comprehending cellular energy metabolism and preventing pathological cell death.
  • Further research into uniporter proteins holds promise for therapeutic strategies targeting cardiovascular diseases and other conditions involving mitochondrial dysfunction.