Related Experiment Video
Updated: Dec 21, 2025
05:06
Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
15.8K
Bacteriotherapy in gastrointestinal cancer
Saman Soleimanpour1, Seyed Mahdi Hasanian2, Amir Avan3
1Antimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Life Sciences
|May 12, 2020
Summary
Bacteria show promise as novel anticancer agents for gastrointestinal cancers, offering a potential alternative to traditional therapies. This review explores bacteriotherapy and its genetic modifications for enhanced efficacy in treating colorectal, stomach, and liver cancers.
Area of Science:
- Oncology
- Microbiology
- Biotechnology
Background:
- Gastrointestinal (GI) cancers, including colorectal, stomach, and liver cancers, are leading causes of cancer-related mortality worldwide.
- Conventional treatments like surgery, radiotherapy, and chemotherapy often prove ineffective for many cancer patients.
- There is a critical need for novel and effective anticancer therapeutic strategies.
Purpose of the Study:
- To conduct a comprehensive review of current literature on bacteriotherapy for gastrointestinal cancers.
- To explore the potential of bacteria and their substances (bacteriocins, toxins) as anticancer agents.
- To examine the role of genetic engineering in enhancing bacteriotherapy efficacy.
Main Methods:
- Literature review of studies on bacteriotherapy for GI cancers.
- Analysis of bacterial species targeting tumor cells, including live, attenuated, and genetically modified forms.
- Consideration of tumor microenvironment factors like hypoxia in treatment strategies.
Main Results:
- Promising results from studies using bacteria and their substances against various cancer cell lines.
- Evidence of bacterial species specifically targeting and internalizing into tumor cells.
- Potential for genetic engineering to improve bacteriotherapy efficacy and reduce drawbacks.
Conclusions:
- Bacteriotherapy presents a promising avenue for the treatment of gastrointestinal cancers.
- Bacterial agents, including modified strains and their products, can be utilized for tumor suppression.
- Further research into bacteriotherapy holds potential for developing new anticancer therapies.
More Related Videos
Related Concept Videos
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
919
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
919
01:29Inflammatory Bowel Disease IV: Pharmacological Management
372
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
372
01:29Microorganisms in Medicine and Therapeutics
832
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
832
01:29Bacterial Flora of the Large Intestine
1.4K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.4K
01:50What is Monogastric Digestion?
74.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.7K