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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
Published on: March 7, 2017
Pediatric Glioma Outcomes: Predictors of Early Mortality
Xingwang Zhou1, XiaoDong Niu1, Kaijun Sun1
1Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, P. R. China.
Insights
Early mortality in pediatric glioma has decreased over 40 years. Glioblastoma and anaplastic glioma increase risk, while treatments like chemotherapy and radiation reduce it.
Area of Science:
- Pediatric Oncology
- Epidemiology
- Cancer Research
Background:
- Early mortality in pediatric glioma remains a significant concern.
- Understanding predictors of early death is crucial for improving therapeutic strategies.
Purpose of the Study:
- To assess early mortality rates in pediatric glioma.
- To identify independent predictors of early mortality in this population.
Main Methods:
- Utilized SEER*Stat software to extract data on pediatric glioma patients.
- Employed logistic regression to identify factors predicting early mortality.
Main Results:
- Early mortality rates within 1 and 3 months post-diagnosis were 1.32% and 2.44%, respectively.
- Glioblastoma, anaplastic glioma, and oligodendroglioma were identified as risk factors.
- Advanced age, gross total resection, radiation, and chemotherapy were associated with decreased early mortality.
Conclusions:
- A significant decrease in early mortality for pediatric glioma was observed over the past 40 years.
- Key factors influencing early mortality include age at diagnosis, histologic subtype, extent of resection, and treatment modalities (chemotherapy, radiation).
Objective:
To assess the early mortality in pediatric glioma and identify predictors of early mortality, which may provide insight into the therapeutic strategies for children with a high risk of early mortality.
Methods:
We used SEER∗Stat 8.3.5 software to extract data of pediatric glioma from the Surveillance, Epidemiology, and End Results database. Logistical regression to identify the independent factors in predicting early mortality.
Results:
A total of 3035 male and 2741 female patients were enrolled in the present study. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Early mortality decreased significantly during the past 40 years. Our results showed that glioblastoma, anaplastic glioma, and oligodendroglioma were risk factors of early mortality for children diagnosed with glioma, whereas advanced age, gross total resection, radiation, and chemotherapy were associated with decreased early mortality.
Conclusions:
We found a decrease in early mortality during the past 40 years. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Age at diagnosis, histologic subtype, the extent of resection, chemotherapy, and radiation were associated with early mortality in pediatric glioma.
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