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A Comparative Study on Aqueous Chitosan Solution and Various Submucosal Injection Fluids Using a Three-Dimensional

Han Jo Jeon1, Seung Jeong2,3, Hyuk Soon Choi1

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.

Gut and Liver
|May 12, 2020
PubMed
Summary
This summary is machine-generated.

Aqueous chitosan demonstrated superior submucosal injection performance compared to saline and Eleview®, showing promising potential as a biomaterial for endoscopic procedures. This study highlights chitosan

Keywords:
ChitosanEndoscopyImagingInjectionsStomachgastrointestinalthree-dimensional

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Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Polymer Chemistry

Background:

  • Chitosan, a natural polymer, is explored for submucosal injection applications.
  • Current submucosal injection fluids include saline, Eleview®, and Blue Eye™.

Purpose of the Study:

  • Compare the efficacy of aqueous chitosan solution against commercial submucosal injection fluids.
  • Evaluate the performance of a three-dimensional sensor in measuring submucosal fluid cushion properties.

Main Methods:

  • Ex vivo porcine stomach submucosal injection of normal saline, Eleview®, Blue Eye™, and 2.0% aqueous chitosan solution.
  • Measurement of mucosal elevation height, surface area, and fluid cushion angle using a 3D sensor.
  • Histological analysis of tissue specimens.

Main Results:

  • Chitosan injection yielded the highest values for mucosal elevation height, surface area, and angle.
  • Significant differences in elevation height and surface area rates of change were observed between chitosan and control/commercial fluids.
  • Height, area, and angle demonstrated a positive correlation, and chitosan showed no tissue damage.

Conclusions:

  • Aqueous chitosan is superior to normal saline and Eleview® and non-inferior to TS-905 for submucosal injection.
  • The 3D sensor and measured parameters effectively evaluate submucosal fluid performance.