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Is it possible to predict the complexity of peripheral artery disease with atherogenic index?

Engin Mesut1, Aydın Cihan2, Guvenc Orhan3

  • 1Department of Cardiovascular Surgery, University of Health Sciences, Mehmet Akif İnan Training and Research Hospital, Karaköprü/Şanlıurfa, Türkiye.

Vascular
|May 12, 2020
PubMed

Insights

The triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio can predict the complexity of peripheral artery disease (PAD). This atherogenic index, calculated from routine blood tests, offers a valuable tool for assessing disease severity in PAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Atherosclerosis Research
  • Clinical Biochemistry

Background:

  • Peripheral artery disease (PAD) is primarily caused by atherosclerosis, a systemic process.
  • Elevated triglyceride (TG) and reduced high density lipoprotein cholesterol (HDL-C) levels are known risk factors for atherosclerosis.
  • The TG/HDL-C ratio, or atherogenic index, is utilized to assess atherosclerosis risk.

Purpose of the Study:

  • To investigate the predictive value of the TG/HDL-C ratio for the angiographic complexity of lower extremity peripheral artery disease.
  • To determine if the atherogenic index can serve as a reliable marker for disease severity in PAD patients.

Main Methods:

  • Retrospective analysis of patients diagnosed with peripheral artery disease between August 2013 and August 2019.
  • Classification of patients into two groups based on TransAtlantic Inter-Society Consensus-II (TASC) classification: TASC A-B lesions (Group 1) and TASC C-D lesions (Group 2).
  • Statistical analysis including multivariate logistic regression and Receiver Operating Characteristic (ROC) curve analysis to identify predictors of angiographic complexity.

Main Results:

  • Group 2 (TASC C-D) exhibited significantly higher TG and TG/HDL-C ratios, and lower HDL-C compared to Group 1 (TASC A-B).
  • Coronary artery disease and TG/HDL-C ratio were identified as independent predictors of angiographic complexity in PAD.
  • ROC analysis indicated a TG/HDL-C cut-off value of 2.9 (AUC=0.670) for predicting complexity, with 75.5% sensitivity and 56.7% specificity.

Conclusions:

  • The TG/HDL-C ratio is a valuable and easily obtainable predictor of angiographic complexity in patients with peripheral artery disease.
  • Routine biochemical parameters, specifically the atherogenic index, can aid in assessing the severity of PAD.
Abstract

Keywords:
Peripheral arterial diseaseTASC II classificationatherogenic indexhigh density lipoprotein cholesteroltriglyceride

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