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Related Experiment Video

Updated: Dec 21, 2025

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
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Vigilance Effects in Resting-State fMRI.

Thomas T Liu1,2, Maryam Falahpour1

  • 1Center for Functional MRI, University of California, San Diego, La Jolla, CA, United States.

Frontiers in Neuroscience
|May 12, 2020
PubMed
Summary
This summary is machine-generated.

Vigilance, or alertness, significantly impacts brain activity measured by resting-state functional MRI (rsfMRI). Failing to account for vigilance can lead to misinterpreting brain changes as cognitive or disease effects.

Keywords:
EEGarousalfMRIfunctional connectivityvigilancewakefulness

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Medical Imaging

Background:

  • Resting-state functional magnetic resonance imaging (rsfMRI) measures brain activity during rest.
  • rsfMRI is sensitive to cognitive function and disease states.
  • Vigilance variations can significantly alter rsfMRI signals.

Purpose of the Study:

  • To investigate the relationship between vigilance and rsfMRI measures.
  • To understand how vigilance influences brain activity.
  • To review methods for accounting for vigilance in rsfMRI studies.

Main Methods:

  • Analysis of rsfMRI signal variance and functional connectivity.
  • Examination of state changes induced by caffeine and sleep deprivation.
  • Review of current and emerging methodologies for vigilance estimation.

Main Results:

  • Vigilance variations cause widespread changes in rsfMRI activity.
  • Factors like caffeine and sleep deprivation demonstrably affect both vigilance and rsfMRI.
  • Misinterpretation of vigilance-related rsfMRI changes is a significant concern.

Conclusions:

  • Vigilance is a critical confound in rsfMRI research.
  • Accurate assessment and control of vigilance are necessary for valid rsfMRI interpretations.
  • Methodological advancements are needed to address vigilance effects in brain imaging.