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Precision Dosing Priority Criteria: Drug, Disease, and Patient Population Variables
Rachel J Tyson1, Christine C Park1, J Robert Powell1
1Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Frontiers in Pharmacology
|May 12, 2020
Summary
Optimizing drug dosage is crucial for patient outcomes, balancing effectiveness against toxicity. Prioritizing precision dosing targets requires evaluating evidence quality and clinical impact for better patient care.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Development
Background:
- Drug dosage significantly impacts therapeutic effectiveness, toxicity, and patient survival.
- Precision dosing is vital for drugs with narrow therapeutic windows or life-altering effects.
- Current precision dosing strategies are underutilized across many drug-disease contexts.
Purpose of the Study:
- To identify key variables for prioritizing drug-disease targets for precision dosing.
- To explore the evidence requirements for changing drug labels and clinical practice.
- To discuss timely delivery of precision dosing to high-priority patients.
Main Methods:
- Review of existing literature on precision dosing strategies.
- Analysis of factors influencing the prioritization of precision dosing candidates.
- Case study examination of successful precision dosing implementations.
Main Results:
- Evidence quality and potential clinical impact are critical for prioritizing precision dosing.
- Significant differences from approved labels necessitate robust proof for clinical adoption.
- Cost-benefit analysis is essential for resource allocation in precision dosing development.
Conclusions:
- Systematic prioritization of precision dosing targets can enhance patient outcomes.
- Effective implementation requires robust evidence generation and consideration of clinical practice integration.
- Addressing underutilization is key to realizing the full potential of precision dosing.
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