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Updated: Aug 16, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
[Amyloidosis of the kidneys in Crohn disease]
W Schneider1, P Martin, K Meinel
1Abteilung Poliklinik der Klinik, Martin-Luther-Universität Halle-Wittenberg.
Abstract:
At the instance of the variegated anamnesis of a patient with Crohn's disease the unusually rapid development of a secondary amyloidosis of the kidneys is described. Crohn's disease became manifest at the 17th year of age. The severe course of the disease of the last four years with relapsing intraabdominal abscesses and multiple formations of fistulae might be significant for the pathogenesis of the amyloidosis. If the local complications of Crohn's disease are controlled then the amyloidosis still threatens the patient's life. In case the inflammatory process could be cured the consequence would as expected be the alleviation of the amyloidosis. An additional colchicine therapy may then accelerate the process of healing. However, the nature of Crohn's disease is uncertain.
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