Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

5.5K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.5K
Autophagic Cell Death01:18

Autophagic Cell Death

4.2K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.2K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

8.6K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
8.6K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

4.7K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
4.7K
Viruses of Archaea01:29

Viruses of Archaea

374
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
374
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

3.3K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyamine-mediated inhibition of ferroptosis contributes to geroprotection.

Cell stress·2026
Same author

Presenilin-1 controls glycolysis and identity of pancreatic beta cells.

Communications biology·2026
Same author

Do metabolic fluxes change with age?

Trends in endocrinology and metabolism: TEM·2026
Same author

Editing <i>Candida</i>: Origins and Advances of CRISPR Tools.

Biomolecules·2026
Same author

Antifungal peptides: From modes of action to synergistic and immunologic potential.

Cell stress·2026
Same author

The lichen secondary metabolite lichesterinic acid exhibits antibiofilm activity against fungal pathogens.

Frontiers in cellular and infection microbiology·2026

Related Experiment Video

Updated: Dec 21, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

976

Digesting the crisis: autophagy and coronaviruses.

Didac Carmona-Gutierrez1, Maria A Bauer1, Andreas Zimmermann1,2

  • 1Institute for Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.

Microbial Cell (Graz, Austria)
|May 12, 2020
PubMed
Summary

Autophagy plays a key role in antiviral defense and cellular balance. Researchers explore if modulating autophagy can be a therapeutic strategy against SARS-CoV-2, the virus causing COVID-19.

Keywords:
COVID-19MERSSARSSARS-CoV-2coronavirusimmunityinflammationvirophagy

More Related Videos

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.8K
Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
08:16

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection

Published on: July 21, 2022

1.7K

Related Experiment Videos

Last Updated: Dec 21, 2025

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

976
Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body
06:02

Analyzing Starvation-Induced Autophagy in the Drosophila melanogaster Larval Fat Body

Published on: August 4, 2022

2.8K
Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection
08:16

Identifying Caspases and their Motifs that Cleave Proteins During Influenza A Virus Infection

Published on: July 21, 2022

1.7K

Area of Science:

  • Cellular Biology
  • Immunology
  • Virology

Background:

  • Autophagy is a fundamental cellular process crucial for maintaining homeostasis.
  • It plays a significant role in the innate and adaptive immune responses, including antiviral defense.
  • Viruses have evolved strategies to manipulate or evade autophagy for their own benefit.

Purpose of the Study:

  • To review the existing evidence on the interplay between autophagy and coronaviruses.
  • To discuss the potential of targeting autophagy as a therapeutic strategy against SARS-CoV-2.

Main Methods:

  • Literature review and synthesis of current research findings.

Main Results:

  • Autophagy is implicated in multiple facets of the antiviral response, such as viral clearance and immune cell function.
  • Coronaviruses, including SARS-CoV-2, interact with the autophagic pathway, either by evading it or exploiting it for replication.
  • Evidence suggests a complex relationship where autophagy can restrict or promote viral infection depending on the context.

Conclusions:

  • The intricate relationship between autophagy and coronaviruses presents potential therapeutic targets.
  • Further research is warranted to determine if modulating autophagy can be an effective strategy to combat SARS-CoV-2 infection and COVID-19.