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Updated: Dec 21, 2025

Single-cell Microfluidic Analysis of Bacillus subtilis
Published on: January 26, 2018
Microbe Profile: Bacillus subtilis: model organism for cellular development, and industrial workhorse
Jeffery Errington1, Lizah T van der Aart1
1Centre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, NE2 4AX, UK.
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Bacillus subtilis is the best studied model organism of the Gram-positive lineage. It is naturally transformable and has an extremely powerful genetic toolbox. It is fast growing and easy to cultivate. It is an important industrial organism, being proficient at secreting proteins and making small fine chemicals, as well as acting as a plant growth promoter. It has been an important model system for studying biofilms. Finally, it makes endospores, which have provided an exceptionally fruitful system for studying various central problems of cellular development, including the generation of asymmetry, cell fate determination and morphogenesis.
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