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[Genetic Predisposition to Early Myocardial Infarction]
I A Goncharova1,2,3, M S Nazarenko1,2,4, N P Babushkina1
1Research Institute for Medical Genetics, Tomsk, 634050 Russia.
Molekuliarnaia Biologiia
|May 12, 2020
Summary
This study reveals distinct genetic factors influencing early and late myocardial infarction (MI). Specific gene variants in ADAMDEC1 and AQP2 are linked to early-onset MI, while TAS2R38 is associated with late-onset MI.
Area of Science:
- Genetics
- Cardiology
- Molecular Biology
Background:
- Myocardial infarction (MI) susceptibility has a significant genetic component.
- Understanding age-dependent genetic factors can refine risk prediction and prevention strategies for MI.
Purpose of the Study:
- To identify age-specific genetic variations associated with myocardial infarction (MI).
- To differentiate genetic markers for early-onset MI (before 60) versus late-onset MI (after 60).
Main Methods:
- Genotyping of 58 single nucleotide variants (SNPs) in 355 MI patients (121 early, 234 late) and 285 controls using mass spectrometry.
- Statistical analysis using R environment and evaluation of SNP regulatory potential via online services.
- Identification of eQTL loci using GTEx project and Blood eQTL browser data.
Main Results:
- Common MI-associated genotypes include ITGA4 rs1143674 (GG), CDKN2B-AS1 rs1333049 (CC), and KIAA1462 rs3739998 (CC).
- Early MI is associated with ADAMDEC1 rs3765124 (AA) and AQP2 rs2878771 (GG).
- Late MI is associated with TAS2R38 rs1726866 (TT).
- Associated SNPs are regulatory, impacting gene expression and transcription factor binding.
Conclusions:
- Early and late MI share common genetic underpinnings (ITGA4, CDKN2B-AS1, KIAA1462).
- Distinct genetic variants (ADAMDEC1, AQP2 for early MI; TAS2R38 for late MI) contribute to age-specific MI susceptibility.
- These findings highlight the complex genetic architecture of MI across different age groups.
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