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Updated: Dec 21, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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A Practical Guide for Faecal Calprotectin Measurement: Myths and Realities.

Ferdinando D'Amico^1,2, Stéphane Nancey³, Silvio Danese^1,4

¹Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Journal of Crohn'S & Colitis

|May 12, 2020

Summary

Standardizing fecal calprotectin (FC) testing is crucial for accurate inflammatory bowel disease management. This guide offers practical advice to minimize variability and improve interpretation of FC results.

Keywords:

Faecal calprotectin guide inflammatory bowel disease

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Published on: March 10, 2020

Area of Science:

Gastroenterology
Clinical Chemistry

Background:

Faecal calprotectin (FC) is a key non-invasive marker for mucosal inflammation in inflammatory bowel diseases (IBD).
Current lack of standardization in FC testing leads to variability and potential misinterpretation.
Accurate FC measurement is vital for patient follow-up and treatment response prediction.

Purpose of the Study:

To provide a clinician's guide for practical FC measurement.
To minimize confounding factors and variability in FC testing.
To ensure adequate interpretation of FC results for improved patient management.

Main Methods:

Comprehensive literature search of PubMed/MEDLINE, EMBASE, and Cochrane databases up to January 2020.
Focused on pre-analytical and analytical phases of FC measurement.
Identification of factors influencing test accuracy.

Main Results:

FC testing involves pre-analytical (sample collection/processing) and analytical phases.
Numerous factors can influence FC test results, leading to false positives or negatives.
Inaccurate FC data can negatively impact clinical decisions and patient care.

Conclusions:

This review offers practical recommendations to reduce FC dosage variability.
Further research is needed to compare commercial FC assays for precision and accuracy.
Standardization efforts are essential for reliable FC testing in IBD.