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Updated: Dec 21, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Disruption of Placental Homeostasis Leads to Preeclampsia

Akitoshi Nakashima1, Tomoko Shima1, Sayaka Tsuda1

  • 1Department of Obstetrics and Gynecology, University of Toyama, Toyama 930-8555, Japan.

International Journal of Molecular Sciences
|May 13, 2020
PubMed

Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.

Keywords:
autophagyendoplasmic reticulum stressinflammationlysosomesplacentapreeclampsiaprotein aggregationpyroptosis

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